+351 256 811 800 Rede Fixa Nacional geral@carlossousa.pt

Like almost everything in character, magic mushrooms are difficulty to the outcomes of their surrounding surroundings. These variables (what&nbspPaul Stamets&nbspcalls &ldquoa constellation of variables&rdquo&nbspone) include temperature, soil disorders, humidity, competitiveness for usually means, and the affect of health problems and predators. Modifications in just a single or considerably more variables final result anywhere magic mushrooms develop, when, how quite nicely, and the compounds they involve as flawlessly as the quantities of them.

The Compounds in Magic Mushrooms

Magic mushrooms&nbspcontain a cocktail of compounds, some of which result in psychoactive results in people today. Some of the determined compounds in magic mushrooms are&nbsppsilocybin,&nbsppsilocin, norpsilocin,&nbspbaeocystin,&nbspnorbaeocystin, and&nbspaeruginascin. Also, different parts of a mushroom can have various parts of compounds. For example, a single look at noticed the best quantity of cash of&nbsppsilocybinin the caps of&nbspPanaeolus subalteatus&nbspin distinction to the relaxation of the fruiting physique.two

Variability in the Chemical Composition of Wild and Cultivated Magic Mushrooms

Several investigation on wild magic mushrooms have uncovered the sizeable variability in the compounds they incorporate. These variants are witnessed not just from species to species but from batch to batch inside of a species. Also, reports are shedding light on how controlling climbing ailments influences the amount of money and range of active compounds in cultivated magic mushrooms.

Wild Magic Mushrooms

In 1982, scientists Bigwood and Beug pointed out a tenfold change in the&nbsppsilocybin&nbspcontent of&nbspPsilocybe cubensis&nbspcollected in the wild.3&nbspAnother study analyzed fifty two samples of wild&nbspPsilocybe semilanceata&nbspcollected in Switzerland in excessive of 5 yrs. The&nbsppsilocin&nbspcontent varied from .21 to two.02% and&nbspbaeocystin&nbspfrom .05 to .77%.four&nbspTraces of&nbsppsilocin&nbspwere also existing. The researchers determined that variability depended on the age of the mushrooms, their dimensions, and the part of the fruiting full system they examined. A evaluate by Gartz situated the&nbsppsilocybin&nbspcontent of dried&nbspPsilocybe semilanceata&nbspvaried from .19 to 1.34%.5&nbspThe mushrooms with the the very least highly-priced mass experienced the maximum focus of&nbsppsilocybin.

In 1988, Gartz uncovered&nbspaeruginascin&nbspin 10 fruiting bodies of&nbspInocybe aeruginascens.six&nbspHe also talked about a correlation in concerning the amount of money of revenue of&nbsppsilocybin,&nbspbaeocystin, and&nbspaeruginascin&nbspin the fruiting bodies. Jensen et al. researched&nbspaeruginascin&nbspfrom&nbspI. aeruginascens&nbspcollected in Potsdam, Germany.7&nbspThe mushrooms contained varying quantities of&nbsppsilocybin,&nbspbaeocystin,&nbspnorbaeocystin, and&nbspaeruginascin.


The desk beneath reveals information on the aspects in other magic mushrooms.

Table one: Elements in many species of dried&nbspPsilocybe&nbspmushrooms. Taken from the Paul Stamets book&nbspPsilocybin&nbspMushrooms of the Globe.

&nbspFor each cent by Bodyweight of Dried Mushroom Resources&nbsp
P. azurescensone.seventy eight.38.35eight
P. bohemicaa person.34.eleven.02nine, 10
P. baeocystis.eighty 5.fifty nine.10eleven, twelve
P. tampanensis.sixty 8.32n/a10
P. hoogshagenii.sixty.10n/a13
P. stuntzii.36.twelve.02eleven, twelve

Cultivated Magic Mushrooms

Bigwood and Beug recognized a fourfold variance in&nbsppsilocybin&nbspcontent in&nbspPsilocybe cubensis&nbspgrown on rye grain.threeTheir accomplish also uncovered vital conclusions about the quantities of&nbsppsilocybin&nbspand&nbsppsilocin&nbspin successive flushes (one more term for the fruiting or harvesting intervals) of cultivated&nbspP. cubensis. In regular, there was no&nbsppsilocin&nbspin the first and in some scenarios the 2nd flush. The total of&nbsppsilocinreached a best by the fourth flush. The stage of&nbsppsilocybin&nbspshowed no upward or downward enhancement in extra of the technique of quite a few flushes. Having mentioned that, it was variable by about a element of four as fruiting progressed. All spherical, the stage of&nbsppsilocybin&nbspwas close to usually two times that of&nbsppsilocin.

In 1989, Gartz identified that raising the tryptamine focus in a cow dung-rice climbing medium better&nbsppsilocin&nbspcontent in&nbspPsilocybe cubensis&nbspfrom .09% to three.three% of the dried mushroom physique fat.fourteen&nbspAlso, creating use of superior-effectiveness liquid chromatography (HPLC) and slender-layer chromatography (TLC), Gartz found that the mushrooms grown on the tryptamine-enriched mixture contained only a compact volume of&nbsppsilocybin&nbsp(.01 &ndash .two%).

The Synergy of Compounds in Magic Mushrooms &ndash Limitless Probable for New Conclusions

At the instant, scientists don&rsquot absolutely grasp (and are not researching) how the compounds in magic mushrooms interact with just about each other and with serotonin receptors in the brain, especially five-HT2A. It&rsquos attainable that&nbspallosteric modulation&nbspplays a reason in the complete entourage effect.


The scientific trials at this time remaining executed by&nbspCOMPASS Pathways&nbspare generating use of pure&nbsppsilocybin&nbspin&nbsppsilocybin-assisted cure for despair. By on your own,&nbsppsilocybin&nbspcauses several outcomes that it would in the existence of the other compounds ingested when consuming magic mushrooms. read review for this lies in the anecdotal ordeals (like these on&nbspErowid&nbspand&nbspBlueLight) of customers reporting distinct results from ingesting various species of magic mushrooms. Some of these implications are thought of top-quality or interesting these as ideas of euphoria and wonderful visualizations. Other added benefits are substantially fewer attractive these types of as&nbspmuscle weak point and paralysis.

No one particular appreciates how&nbsppsilocybin-assisted solution could strengthen if experts experienced a significantly improved comprehension of the discussion involving&nbspall&nbspof the factors in magic mushrooms. That&rsquos not to say the scientific trials are not credible or considerable. What desires to be comprehended is that&nbsppsilocybinis not the only energetic part or&nbspprodrug&nbspin magic mushrooms. Investigation in this position necessitates to just take a motion back yet again and obtain a further understanding of the chemistry of magic mushrooms.


There are quite a few variables taking care of the variety and sum of cash of compounds discovered in magic mushrooms. As a consequence, these mushrooms have substantial variability in the target and forms of substances they have. The nominal scientific scientific tests carried out so considerably barely scratch the surface of getting familiar with.

Consuming magic mushrooms unleashes a chemical cocktail of possible psychoactive components into the bloodstream, resulting in quite distinct repercussions than ingesting pure&nbsppsilocybin. Recognition of this notion in the scientific team is preferred, followed by conducting supplemental research into figuring out the specific outcomes and interactions of magic mushroom elements.